Conclusions: Blue laser light (445 nm) demonstrates antimicrobial activity, which increases with prolonged exposure. Further research is needed to assess all key influencing parameters and define possible clinical applications. In dentistry, blue light could be used, for example, in the treatment of periodontitis/peri-implantitis, as well. Blue light primarily exhibits antimicrobial activity through the activation of endogenous photosensitizers, which leads to the formation of reactive oxygen species that attack components of bacterial cells. This offers a promising alternative or complement to traditional methods for controlling microbial growth. Here, we report the efficacy of blue laser light in eradicating Pseudomonas. The new tool is based on more than a decade of Wellman Center research in preclinical models revealing that blue light can curtail even the most stubborn bacterial pathogens.
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