Prebiotic origin of pre-RNA building blocks in a urea "warm little pond
We propose a model for the origin of a variety of canonical and non-canonical nucleobases, including some known to form supramolecular assemblies that contain Watson-Crick-like base pairs.
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Prebiotic Origin of Pre-RNA Building Blocks in a Urea "Warm Little Pond
These reactions involve urea condensation with other prebiotic molecules (e. g., malonic acid) that could be driven by environmental cycles (e. g., freezing/thawing, drying/wetting).
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Prebiotic Origin of Pre‐RNA Building Blocks in a Urea “Warm Little Pond
In summary, we have shown that the condensation of malonic acid and urea or urea/guanidine in a prebiotic scenario, as might have existed on the prebiotic Earth in evaporating warm ponds at
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Prebiotic origin of pre-RNA building blocks in a urea "warm little pond
In the presence of aldose sugars, bases from these pools could react with the sugars through spontaneous glycosylation, ultimately concentrating de novo nucleosides through aggregation. We
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Prebiotic Origin of Pre‐RNA Building Blocks in a Urea
After 5 days of wet/dry 14 interest for chemical evolution, in a prebiotic urea-rich „warm cycles at 65 °C, a mixture containing pyrimidines was formed 15 little pond“ using malonic acid as precursor.